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Targeting claudin-overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin.

Molecular oncology - 1 Feb 2020

Piontek Anna, Eichner Miriam, Zwanziger Denise, Beier Laura-Sophie, Protze Jonas, Walther Wolfgang, Theurer Sarah, Schmid Kurt Werner, Führer-Sakel Dagmar, Piontek Jörg, Krause Gerd

Abstract excerpt

Clostridium perfringens enterotoxin (CPE) can be used to eliminate carcinoma cells that overexpress on their cell surface CPE receptors - a subset of claudins (e.g., Cldn3 and Cldn4). However, CPE cannot target tumors expressing solely CPE-insensitive claudins (such as Cldn1 and Cldn5). To overcome this limitation, structure-guided modifications were used to generate CPE variants that can strongly bind to Cldn1,...

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Identifiers

PMID: 31825142
DOI: 10.1002/1878-0261.12615
PMCID: PMC6998413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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