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Article

Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies

14 Feb 2013

Abstract excerpt

HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of resting memory CD4(+) T cells carrying latent but replication-competent viral genomes. Because strategies targeting this latent reservoir are now being tested in clinical trials, well-validated high-throughput assays that...

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PMID: 23459007
DOI: 10.1371/journal.ppat.1003174

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