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Article

Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

Cell - 24 Oct 2013

Ho Ya-Chi, Shan Liang, Hosmane Nina N, Wang Jeffrey, Laskey Sarah B, Rosenbloom Daniel I S, Lai Jun, Blankson Joel N, Siliciano Janet D, Siliciano Robert F

Abstract excerpt

Antiretroviral therapy fails to cure HIV-1 infection because latent proviruses persist in resting CD4(+) T cells. T cell activation reverses latency, but <1% of proviruses are induced to release infectious virus after maximum in vitro activation. The noninduced proviruses are generally considered defective but have not been characterized. Analysis of 213 noninduced proviral clones from treated patients showed...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24243014
DOI: 10.1016/j.cell.2013.09.020
PMCID: PMC3896327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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