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Article

A novel assay allows genotyping of the latent reservoir for human immunodeficiency virus type 1 in the resting CD4+ T cells of viremic patients.

Journal of virology - 1 Apr 2005

Monie Daphne, Simmons Rachel P, Nettles Richard E, Kieffer Tara L, Zhou Yan, Zhang Haili, Karmon Sharon, Ingersoll Roxann, Chadwick Karen, Zhang Hao, Margolick Joseph B, Quinn Thomas C, Ray Stuart C, Wind-Rotolo Megan, Miller Michael, Persaud Deborah, Siliciano Robert F

Abstract excerpt

A latent reservoir for human immunodeficiency virus type 1 (HIV-1) consisting of integrated provirus in resting memory CD4+ T cells prevents viral eradication in patients on highly active antiretroviral therapy (HAART). It is difficult to analyze the nature and dynamics of this reservoir in untreated patients and in patients failing therapy, because it is obscured by an excess of unintegrated viral DNA that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15795302
DOI: 10.1128/JVI.79.8.5185-5202.2005
PMCID: PMC1069549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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