Article
Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes.
The Journal of infectious diseases - 1 Mar 2009
Simen Birgitte B, Simons Jan Fredrik, Hullsiek Katherine Huppler, Novak Richard M, Macarthur Rodger D, Baxter John D, Huang Chunli, Lubeski Christine, Turenchalk Gregory S, Braverman Michael S, Desany Brian, Rothberg Jonathan M, Egholm Michael, Kozal Michael J
Abstract excerpt
BACKGROUND: Minor (i.e., <20% prevalence) drug-resistant human immunodeficiency virus (HIV) variants may go undetected, yet be clinically important. OBJECTIVES: To compare the prevalence of drug-resistant variants detected with standard and ultra-deep sequencing (detection down to 1% prevalence) and to determine the impact of minor resistant variants on virologic failure (VF). METHODS: The Flexible Initial...
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