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Article

Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart.

Circulation research - 19 Mar 2010

Kimura Tomomi E, Jin Jiawei, Zi Min, Prehar Sukhpal, Liu Wei, Oceandy Delvac, Abe Jun-ichi, Neyses Ludwig, Weston Arthur H, Cartwright Elizabeth J, Wang Xin

Abstract excerpt

RATIONALE: Mitogen-activated protein kinase (MAPK) pathways provide a critical connection between extrinsic and intrinsic signals to cardiac hypertrophy. Extracellular signal-regulated protein kinase (ERK)5, an atypical MAPK is activated in the heart by pressure overload. However, the role of ERK5 plays in regulating hypertrophic growth and hypertrophy-induced apoptosis is not completely understood. OBJECTIVE:...

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Identifiers

PMID: 20075332
DOI: 10.1161/CIRCRESAHA.109.209320
PMCID: PMC3003662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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