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Article

Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy.

The Journal of cell biology - 27 Oct 2014

Nandi Nilay, Tyra Lauren K, Stenesen Drew, Krämer Helmut

Abstract excerpt

How cellular stresses up-regulate autophagy is not fully understood. One potential regulator is the Drosophila melanogaster protein Acinus (Acn), which is necessary for autophagy induction and triggers excess autophagy when overexpressed. We show that cell type-specific regulation of Acn depends on proteolysis by the caspase Dcp-1. Basal Dcp-1 activity in developing photoreceptors is sufficient for this cleavage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25332163
DOI: 10.1083/jcb.201404028
PMCID: PMC4210446

Genes

AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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