Article

A phospho-switch at Acinus-Serine <sup>437</sup> controls autophagic responses to Cadmium exposure and neurodegenerative stress

2021-07-28

Abstract excerpt

<h4>Summary</h4> Neuronal health depends on quality control functions of autophagy, but mechanisms regulating neuronal autophagy are poorly understood. Previously, we showed that in Drosophila starvation-independent quality control autophagy is regulated by Acinus and the Cdk5-dependent phosphorylation of its serine 437 (Nandi et al., 2017). Here, we identify the phosphatase that counterbalances this activity an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af38c556-719b-5a0f-8ae5-6cf988da939c
DOI: 10.1101/2021.07.27.453988

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A phospho-switch at Acinus-Serine <sup>437</sup> controls autophagic responses to Cadmium exposure and neurodegenerative stressDOI 10.1101/2021.07.27.453988Read

Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress‐induced autophagySemantic proximity Read

Acinus: a nuclear regulator of autophagy and endocytic trafficking.Semantic proximity Read

A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during agingSemantic proximity Read

Phosphate Restriction Promotes Longevity via Activation of Autophagy and the Multivesicular Body PathwaySemantic proximity Read

Regulation of Human PINK1 ubiquitin kinase by Serine167, Serine228 and Cysteine412 phosphorylationSemantic proximity Read

Rescue of Pink1 Deficiency by Stress-Dependent Activation of AutophagySemantic proximity Read

A Saposin deficiency model in <i>Drosophila</i> : lysosomal storage, progressive neurodegeneration, sensory physiological decline and defective calcium homeostasisSemantic proximity Read

α-synucleinopathy associated calcium overload and autophagy failure is regulated by gain-of-function of Tousled-like kinaseSemantic proximity Read

Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy.Semantic proximity Read

Scd5p mediates phosphoregulation of actin and endocytosis by the type 1 phosphatase Glc7p in yeast.Semantic proximity Read

The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein.Semantic proximity Read

Critical cysteines in Akt1 regulate its activity and proteasomal degradation: implications for neurodegenerative diseases.Semantic proximity Read