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Article

JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy.

Mechanisms of development - 1 Jan 2000

Wu Hai, Wang Meng C, Bohmann Dirk

Abstract excerpt

JNK signaling functions to induce defense mechanisms that protect organisms against acute oxidative and xenobiotic insults. Using Drosophila as a model system, we investigated the role of autophagy as such a JNK-regulated protective mechanism. We show that oxidative stress can induce autophagy in the intestinal epithelium by a mechanism that requires JNK signaling. Consistently, artificial activation of JNK in...

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Identifiers

PMID: 19540338
DOI: 10.1016/j.mod.2009.06.1082
PMCID: PMC2750887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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