High <i> <scp>EVI</scp> 1 </i> expression is associated with <i> <scp>MLL</scp> </i> rearrangements and predicts decreased survival in paediatric acute myeloid leukaemia: a report from the children's oncology group

Abstract excerpt

Ectopic viral integration site-1 (EVI1) is highly expressed in certain cytogenetic subsets of adult acute myeloid leukaemia (AML), and has been associated with inferior survival. We sought to examine the clinical and biological associations of EVI1(high) , defined as expression in excess of normal controls, in paediatric AML. EVI1 mRNA expression was measured via quantitative real-time polymerase chain reaction...

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