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Conserved Motifs within Ebola and Marburg Virus VP40 Proteins Are Important for Stability, Localization, and Subsequent Budding of Virus-Like Particles

24 Dec 2009

Abstract excerpt

The filovirus VP40 protein is capable of budding from mammalian cells in the form of virus-like particles (VLPs) that are morphologically indistinguishable from infectious virions. Ebola virus VP40 (eVP40) contains well-characterized overlapping L domains, which play a key role in mediating efficient virus egress. L domains represent only one component required for efficient budding and, therefore, there is a...

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PMID: 20032189
DOI: 10.1128/jvi.02034-09

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Conserved Motifs within Ebola and Marburg Virus VP40 Proteins Are Important for Stability, Localization, and Subsequent Budding of Virus-Like ParticlesPMID 20032189Read ↗

A loop region in the N-terminal domain of Ebola virus VP40 is important in viral assembly, budding, and egress.Semantic proximity Read ↗

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Subcellular Characterization of the Molecular Determinants of Ebola VP40 Trafficking and AssemblySemantic proximity Read ↗

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