Article
Discovering Single Nucleotide Polymorphisms Regulating Human Gene Expression Using Allele Specific Expression from RNA-seq Data.
Genetics - 1 Nov 2016
Kang Eun Yong, Martin Lisa J, Mangul Serghei, Isvilanonda Warin, Zou Jennifer, Ben-David Eyal, Han Buhm, Lusis Aldons J, Shifman Sagiv, Eskin Eleazar
Abstract excerpt
The study of the genetics of gene expression is of considerable importance to understanding the nature of common, complex diseases. The most widely applied approach to identifying relationships between genetic variation and gene expression is the expression quantitative trait loci (eQTL) approach. Here, we increased the computational power of eQTL with an alternative and complementary approach based on analyzing...
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