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Article

Drosophila casein kinase 2 (CK2) promotes warts protein to suppress Yorkie protein activity for growth control.

The Journal of biological chemistry - 28 Nov 2014

Hu Lianxin, Huang Hongling, Li Jinhui, Yin Meng-Xin, Lu Yi, Wu Wenqing, Zeng Rong, Jiang Jin, Zhao Yun, Zhang Lei

Abstract excerpt

Drosophila Hippo signaling regulates Wts activity to phosphorylate and inhibit Yki in order to control tissue growth. CK2 is widely expressed and involved in a variety of signaling pathways. In this study we report that Drosophila CK2 promotes Wts activity to phosphorylate and inhibit Yki activity, which is independent of Hpo-induced Wts promotion. In vivo, CK2 overexpression suppresses hpo mutant-induced...

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Identifiers

PMID: 25320084
DOI: 10.1074/jbc.M114.580456
PMCID: PMC4246111

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Drosophila casein kinase 2 (CK2) promotes warts protein to suppress Yorkie protein activity for growth control.PMID 25320084Read ↗

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.Semantic proximity Read ↗

Elucidation of a universal size-control mechanism in Drosophila and mammals.Semantic proximity Read ↗

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.Semantic proximity Read ↗

Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila.Semantic proximity Read ↗

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.Semantic proximity Read ↗

A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie.Semantic proximity Read ↗

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.Semantic proximity Read ↗

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.Semantic proximity Read ↗

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage.Semantic proximity Read ↗

Control of mitochondrial dynamics by dPGC1 limits Yorkie-induced oncogenic growth in <i>Drosophila</i>Semantic proximity Read ↗

A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock.Semantic proximity Read ↗

The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression.Semantic proximity Read ↗

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