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Article

Low frequency of HNPCC-associated microsatellite instability and aberrant MMR protein expression in early-onset bladder cancer.

American journal of clinical pathology - 1 Nov 2014

Giedl Johannes, Schneckenpointner Roland, Filbeck Thomas, Ruemmele Petra, Hofstaedter Ferdinand, Burger Maximilian, Hartmann Arndt, Stoehr Robert

Abstract excerpt

OBJECTIVES: Recently, it was shown that patients with Lynch syndrome due to an MSH2 mutation are at increased risk for the development of bladder cancer. To further this discussion, we screened the largest investigated cohort of patients with early-onset bladder cancer for microsatellite instability (MSI) and mismatch repair (MMR) deficiency to determine a possible role of Lynch syndrome in young patients with...

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Source

Identifiers

PMID: 25319978
DOI: 10.1309/AJCPVTCJ4VU5HKVZ

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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