Article
Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers.
Journal of medical genetics - 1 Jul 2010
van der Post R S, Kiemeney L A, Ligtenberg M J L, Witjes J A, Hulsbergen-van de Kaa C A, Bodmer D, Schaap L, Kets C M, van Krieken J H J M, Hoogerbrugge N
Abstract excerpt
BACKGROUND: Colorectal, endometrial and upper urinary tract tumours are characteristic for Lynch syndrome (hereditary non-polyposis colon carcinoma, HNPCC). The aim of the present study was to establish whether carriers of mutations in mismatch repair genes MLH1, MSH2 or MSH6 are at increased risk of urinary bladder cancer. METHODS: Carriers and first degree relatives of 95 families with a germline mutation in...
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