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Article

Low frequency of defective mismatch repair in a population-based series of upper urothelial carcinoma

1 Mar 2005

Abstract excerpt

BACKGROUND: Upper urothelial cancer (UUC), i.e. transitional cell carcinomas of the renal pelvis and the ureter, occur at an increased frequency in patients with hereditary nonpolyposis colorectal cancer (HNPCC). Defective mismatch repair (MMR) specifically characterizes HNPCC-associated tumors, but also occurs in subsets of some sporadic tumors, e.g. in gastrointestinal cancer and endometrial cancer. METHODS: We...

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PMID: 15740628
DOI: 10.1186/1471-2407-5-23

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