Article
Long-term expression of the lamin A mutant associated with dilated cardiomyopathy induces senescence.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2014
Moriuchi Takanobu, Muraoka Takuya, Mio Kazuhiro, Osumi Takashi, Hirose Fumiko
Abstract excerpt
Mutation of the lamin A gene (LMNA) causes a diverse range of diseases referred to as laminopathies. Because most laminopathies have a dominant inheritance pattern and progress gradually, cultured cells stably expressing mutant lamin A at the same level as endogenous wild-type cells are required for chronological analysis. In this study, we showed that an expression system involving a lentiviral vector that...
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