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Article

In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients.

Journal of medical genetics - 1 Aug 2005

Sylvius N, Bilinska Z T, Veinot J P, Fidzianska A, Bolongo P M, Poon S, McKeown P, Davies R A, Chan K-L, Tang A S L, Dyack S, Grzybowski J, Ruzyllo W, McBride H, Tesson F

Abstract excerpt

CONTEXT: Lamin A/C (LMNA) gene variations have been reported in more than one third of genotyped families with dilated cardiomyopathy (DCM). However, the relationship between LMNA mutation and the development of DCM is poorly understood. METHODS AND RESULTS: We found that end stage DCM patients carrying LMNA mutations displayed either dramatic ultrastructural changes of the cardiomyocyte nucleus (D192G) or...

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Share to Cardiomyopathy, Dilated
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COS Cells

Share to Lamin Type A

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Share to Myocytes, Cardiac

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Source

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Identifiers

PMID: 16061563
DOI: 10.1136/jmg.2004.023283
PMCID: PMC1736117

Genes

LMNA
SUMO1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients.PMID 16061563Read ↗

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