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Article

Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia.

Journal of molecular medicine (Berlin, Germany) - 1 Mar 2008

Geiger Stephanie K, Bär Harald, Ehlermann Philipp, Wälde Sarah, Rutschow Désirée, Zeller Raphael, Ivandic Boris T, Zentgraf Hanswalter, Katus Hugo A, Herrmann Harald, Weichenhan Dieter

Abstract excerpt

We have identified a family in which several members died of sudden cardiac death or suffer from dilated cardiomyopathy (DCM) and rhythm disturbances. Mutation screening revealed co-segregation of a novel nonsense mutation (pR321X) in the lamin A gene, LMNA, with the disease. Lamin A, and its smaller splice form lamin C are nuclear intermediate filament proteins forming a major part of the lamina, which is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17987279
DOI: 10.1007/s00109-007-0275-1

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia.PMID 17987279Read ↗

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