Article
Laminopathy-inducing lamin A mutants can induce redistribution of lamin binding proteins into nuclear aggregates.
Experimental cell research - 15 Jan 2006
Hübner S, Eam J E, Hübner A, Jans D A
Abstract excerpt
Lamins, members of the family of intermediate filaments, form a supportive nucleoskeletal structure underlying the nuclear envelope and can also form intranuclear structures. Mutations within the A-type lamin gene cause a variety of degenerative diseases which are collectively referred to as laminopathies. At the molecular level, laminopathies have been shown to be linked to a discontinuous localization pattern...
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