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Article

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.

Nature communications - 15 Oct 2014

Godena Vinay K, Brookes-Hocking Nicholas, Moller Annekathrin, Shaw Gary, Oswald Matthew, Sancho Rosa M, Miller Christopher C J, Whitworth Alexander J, De Vos Kurt J

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. LRRK2 is a multifunctional protein affecting many cellular processes and has been described to bind microtubules. Defective microtubule-based axonal transport is hypothesized to contribute to Parkinson's disease, but whether LRRK2 mutations affect this process to mediate pathogenesis is not known. Here we find...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25316291
DOI: 10.1038/ncomms6245
PMCID: PMC4208097

Genes

HDAC6

Provenance

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Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.PMID 25316291Read ↗

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