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Article

Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy.

Nature communications - 8 Mar 2018

Mo Zhongying, Zhao Xiaobei, Liu Huaqing, Hu Qinghua, Chen Xu-Qiao, Pham Jessica, Wei Na, Liu Ze, Zhou Jiadong, Burgess Robert W, Pfaff Samuel L, Caskey C Thomas, Wu Chengbiao, Bai Ge, Yang Xiang-Lei

Abstract excerpt

Dominant mutations in glycyl-tRNA synthetase (GlyRS) cause a subtype of Charcot-Marie-Tooth neuropathy (CMT2D). Although previous studies have shown that GlyRS mutants aberrantly interact with Nrp1, giving insight into the disease's specific effects on motor neurons, these cannot explain length-dependent axonal degeneration. Here, we report that GlyRS mutants interact aberrantly with HDAC6 and stimulate its...

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Source

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Identifiers

PMID: 29520015
DOI: 10.1038/s41467-018-03461-z
PMCID: PMC5843656

Genes

HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy.PMID 29520015Read ↗

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