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Article

GEN1 from a thermophilic fungus is functionally closely similar to non-eukaryotic junction-resolving enzymes.

Journal of molecular biology - 12 Dec 2014

Freeman Alasdair D J, Liu Yijin, Déclais Anne-Cécile, Gartner Anton, Lilley David M J

Abstract excerpt

Processing of Holliday junctions is essential in recombination. We have identified the gene for the junction-resolving enzyme GEN1 from the thermophilic fungus Chaetomium thermophilum and expressed the N-terminal 487-amino-acid section. The protein is a nuclease that is highly selective for four-way DNA junctions, cleaving 1nt 3' to the point of strand exchange on two strands symmetrically disposed about a...

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Identifiers

PMID: 25315822
DOI: 10.1016/j.jmb.2014.10.008
PMCID: PMC4270448

Genes

GEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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