Diagnostic procedures for improving of the KIT (CD117) expressed allele burden for the liver metastases from uterus mast cell tumors: prognostic value of the metastatic pattern and tumor biology.

doi:10.1007/s13277-014-2666-6

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Article

Diagnostic procedures for improving of the KIT (CD117) expressed allele burden for the liver metastases from uterus mast cell tumors: prognostic value of the metastatic pattern and tumor biology.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Feb 2015

Hosseini Ehsan, Pedram Behnam, Bahrami Ali Mohammad, Touni Seyed Rashid, Malayeri Hamed Zamankhan, Mokarizadeh Aram, Pourzaer Mehdi, Pourzaer Maryam, Zehtabian Shahram, Mohajer Sheida, Ahmadi Sharareh

Abstract excerpt

The activating KIT marker plays a central role in the pathogenesis, diagnosis, and targeted treatment of systemic mastocytosis (SM). Recent studies have identified the KIT (CD117) as a marker that distinguishes nonneoplastic from neoplastic mast cells in human systemic mastocytosis. In this study, we conclude that immunohistopathology assays for KIT staining pattern are useful complimentary tools for diagnosis...

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PMID: 25315185
DOI: 10.1007/s13277-014-2666-6

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