Article
KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients.
Blood - 1 Oct 2006
Garcia-Montero Andres C, Jara-Acevedo Maria, Teodosio Cristina, Sanchez Maria Luz, Nunez Rosa, Prados Aranzazu, Aldanondo Isabel, Sanchez Laura, Dominguez Mercedes, Botana Luis M, Sanchez-Jimenez Francisca, Sotlar Karl, Almeida Julia, Escribano Luis, Orfao Alberto
Abstract excerpt
Despite the relevance of the c-kit/stem cell factor (SCF) signaling pathway in mast cell (MC) diseases, the exact frequency of KIT mutations in different compartments of bone marrow (BM) hematopoietic cells of individuals with systemic mastocytosis (SM), and its different diagnostic categories, remains unknown. In this study, we prospectively analyzed the presence of KIT mutations in fluorescence-activated...
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