Article
KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Sept 2005
Miettinen Markku, Lasota Jerzy
Abstract excerpt
CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the stem cell factor. This leads to a phosphorylation cascade ultimately activating various transcription factors in different cell types. Such activation regulates apoptosis, cell differentiation, proliferation, chemotaxis, and cell...
Topics
- Gene Expression Regulation, Neoplastic
- Humans
- Mutation
- Neoplasms
- Proto-Oncogene Proteins c-kit