Article
Distinct clinical, laboratory, molecular, and pathologic features of systemic mastocytosis involving the gastrointestinal tract.
American journal of clinical pathology - 1 Dec 2025
Chiu April, Viswanatha David S, He Rong, Majerus Julie A, Reichard Kaaren K, Tefferi Ayalew, Pardanani Animesh, Chen Dong
Abstract excerpt
OBJECTIVE: Gastrointestinal (GI) symptoms are common in systemic mastocytosis (SM). We hereby report the clinicopathologic and molecular features of GI mastocytosis. METHODS: The study includes 104 patients with suspected SM. Of 258 GI biopsy -specimens, 33 (20 patients, 19%) were mastocytosis-positive, with 19 (16 patients) initially missed. RESULTS: Tryptase (n = 29) was weakly positive/negative in two-thirds...
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