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Article

IFITM3 polymorphism rs12252-C restricts influenza A viruses.

PloS one - 1 Jan 2014

Williams David Evan Joseph, Wu Wan-Lin, Grotefend Christopher Robert, Radic Vladimir, Chung Changik, Chung Young-Hwa, Farzan Michael, Huang I-Chueh

Abstract excerpt

The IFITM3 polymorphism rs12252-C, which encodes an IFITM3 isoform (Δ21 IFITM3) lacking 21 amino acids at the amino terminus, has been controversially associated with poor clinical outcomes in patients with H1N1 influenza A virus (IAV) infections. In vitro studies have shown that Δ21 IFITM3 loses...

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Source

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Identifiers

PMID: 25314048
DOI: 10.1371/journal.pone.0110096
PMCID: PMC4196997

Genes

IFITM3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25314048-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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IFITM3 polymorphism rs12252-C restricts influenza A viruses.PMID 25314048Read ↗

Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection.Semantic proximity Read ↗

The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication.Semantic proximity Read ↗

The N-terminal region of IFITM3 modulates its antiviral activity by regulating IFITM3 cellular localization.Semantic proximity Read ↗

IFITM3 rs12252 T>C polymorphism is associated with the risk of severe influenza: a meta-analysis.Semantic proximity Read ↗

Association between IFITM3 rs12252 polymorphism and influenza susceptibility and severity: A meta-analysis.Semantic proximity Read ↗

IFITM3 Inhibits SARS-CoV-2 Infection and Is Associated with COVID-19 Susceptibility.Semantic proximity Read ↗

IFITM3 variants point to a critical role in emergent virus infections.Semantic proximity Read ↗

The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 infection and severity of COVID-19.Semantic proximity Read ↗

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The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19.Semantic proximity Read ↗

No Correlation of the Disease Severity of Influenza A Virus Infection with the rs12252 Polymorphism of the Interferon-Induced Transmembrane Protein 3 Gene.Semantic proximity Read ↗

IFITM3 affects the level of antibody response after influenza vaccination.Semantic proximity Read ↗

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