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Immune checkpoint markers and tumour mutation burden in Wilms tumour: a study of 59 cases.

Pathology - 1 Oct 2024

Mattis Aidas J, Chen Jie-Fu, Gonzalez Ivan A, Rais Rehan, Dehner Louis P, Pfeifer John, He Mai

Abstract excerpt

Wilms tumour (WT) is the most common renal tumour in children, and studies of immune checkpoint inhibitors (ICIs) treatment and markers are limited in number. In this study we investigated the ICIs' related immune landscape by examining the expression of PD-L1, PD-1, CD8 and DNA mismatch repair (MMR) proteins by immunohistochemistry (IHC), tumour mutation burden (TMB), and correlations with histology and clinical...

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Share to B7-H1 Antigen
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38879422
DOI: 10.1016/j.pathol.2024.03.005

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