Article
Association of TP53 polymorphisms on the risk of Wilms tumor.
Pediatric blood & cancer - 1 Mar 2014
Andrade R C, Cardoso L C A, Ferman S E, Faria P S, Seuánez H N, Achatz M I, Vargas F R
Abstract excerpt
BACKGROUND: Molecular factors influencing Wilms tumor (WT) development remain largely unknown. TP53 mutations seem to be restricted to the anaplastic WT subtype. However, TP53 polymorphisms do not have a defined role in the disease. PROCEDURE: To assess the impact of TP53 mutations and polymorphisms (PIN2, PIN3, and PEX4) on risk of development, age at diagnosis, and survival in WT, we analyzed 46 blood DNA...
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