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Article

Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis

1 Jan 2010

Abstract excerpt

BACKGROUND: Prostate cancer (PCa) cells preferentially metastasize to bone at least in part by acquiring osteomimetic properties. Runx2, an osteoblast master transcription factor, is aberrantly expressed in PCa cells, and promotes their metastatic phenotype. The transcriptional programs regulated by Runx2 have been extensively studied during osteoblastogenesis, where it activates or represses target genes in a...

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PMID: 20863401
DOI: 10.1186/1476-4598-9-258

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