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Article

Human dermal stem cells differentiate into functional epidermal melanocytes

17 Feb 2010

Abstract excerpt

Melanocytes sustain a lifelong proliferative potential, but a stem cell reservoir in glabrous skin has not yet been found. Here, we show that multipotent dermal stem cells isolated from human foreskins lacking hair follicles are able to home to the epidermis to differentiate into melanocytes. These dermal stem cells, grown as three-dimensional spheres, displayed a capacity for self-renewal and expressed NGFRp75,...

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PMID: 20159965
DOI: 10.1242/jcs.061598

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