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Article

Melanoma, a tumor based on a mutant stem cell?

The Journal of investigative dermatology - 1 Jan 2006

Grichnik James M, Burch James A, Schulteis Ryan D, Shan Siqing, Liu Jie, Darrow Timothy L, Vervaert Carol E, Seigler Hilliard F

Abstract excerpt

Stem cells play a critical role in normal tissue maintenance, and mutations in these stem cells may give rise to cancer. We hypothesize that melanoma develops from a mutated stem cell and therefore residual stem cell characteristics should be able to be identified in melanoma cell lines. We studied three metastatic melanoma cell lines that exhibited multiple morphologic forms in culture and demonstrated the...

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Identifiers

PMID: 16417230
DOI: 10.1038/sj.jid.5700017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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