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Article

Multilineage differentiation drives hamartoma formation in large-to-giant congenital melanocytic naevi: evidence for naevocyte multipotency.

The British journal of dermatology - 19 Mar 2026

Wei Boxuan, Zhu Danli, Jin Jiamin, Lai Bohan, Gu Jieyu, Yan Yuxin, Meng Jianxia, Yang Ran, Huang Huailiang, Lin Hongzhan, Li Qingfeng, Huang Xin, Xie Feng, Zan Tao

Abstract excerpt

BACKGROUND: Large-to-giant congenital melanocytic naevi (LGCMNs) often develop nodules that contain ectopic tissues (hamartomas), which are rarely observed in small-to-medium congenital melanocytic naevi (SMCMNs). The origin and mechanism of the hamartomas formed in LGCMNs remain unknown. OBJECTIVES: To investigate the origin and mechanism of hamartoma formation in LGCMNs, and to evaluate the stemness and...

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Cell Differentiation
Cell Lineage
Exome Sequencing
Hamartoma
Melanocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multipotent Stem Cells

Nevus, Pigmented

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PMID: 41746261
DOI: 10.1093/bjd/ljaf497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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