Article
Cervical cancer cell supernatants induce a phenotypic switch from U937-derived macrophage-activated M1 state into M2-like suppressor phenotype with change in Toll-like receptor profile.
BioMed research international - 1 Jan 2014
Sánchez-Reyes Karina, Bravo-Cuellar Alejandro, Hernández-Flores Georgina, Lerma-Díaz José Manuel, Jave-Suárez Luis Felipe, Gómez-Lomelí Paulina, de Celis Ruth, Aguilar-Lemarroy Adriana, Domínguez-Rodríguez Jorge Ramiro, Ortiz-Lazareno Pablo Cesar
Abstract excerpt
UNLABELLED: Cervical cancer (CC) is the second most common cancer among women worldwide. Infection with human papillomavirus (HPV) is the main risk factor for developing CC. Macrophages are important immune effector cells; they can be differentiated into two phenotypes, identified as M1 (classically activated) and M2 (alternatively activated). Macrophage polarization exerts profound effects on the Toll-like...
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