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Article

Influence of tumor cell culture supernatants on macrophage functional polarization: in vitro models of macrophage-tumor environment interaction.

Tumori - 1 Jan 2000

Caras Iuliana, Tucureanu Catalin, Lerescu Lucian, Pitica Ramona, Melinceanu Laura, Neagu Stefan, Salageanu Aurora

Abstract excerpt

AIMS AND BACKGROUND: Macrophages are heterogeneous cells with extensive functional plasticity; they can change their functional profiles repeatedly in response to environmental changes anywhere between their extreme phenotypical programs (labeled as M1 and M2 polarization, respectively). In terms of antitumoral immune response, M1 macrophages are considered to be beneficial, while M2 macrophages supposedly...

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PMID: 22158498
DOI: 10.1177/030089161109700518

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