Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1.

doi:10.1016/0092-8674(95)90540-5

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Article

Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1.

Cell - 2 Jun 1995

Grieder N C, Nellen D, Burke R, Basler K, Affolter M

Abstract excerpt

Cytokines of the TGF beta superfamily regulate many aspects of cellular function by activating receptor complexes consisting of two distantly related serine/threonine kinases. Previous studies have indicated that Drosophila dpp uses similar signaling complexes and strictly requires the punt and thick veins receptors to transduce the signal across the membrane. Here, we show that the schnurri (shn) gene is...

Topics

Activin Receptors
Amino Acid Sequence
Animals
Cell Differentiation
Cloning, Molecular
DNA-Binding Proteins
Digestive System
Drosophila
Drosophila Proteins
Endoderm
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Insect

In Situ Hybridization

Insect Hormones

Mesoderm

Molecular Sequence Data

Mutation

Phenotype

Source

Open in PubMed

Identifiers

PMID: 7774018
DOI: 10.1016/0092-8674(95)90540-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7774018-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1.PMID 7774018Read ↗

The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family.Semantic proximity Read ↗

A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling.Semantic proximity Read ↗

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The Dpp/TGFβ-Dependent Corepressor Schnurri Protects Epithelial Cells from JNK-Induced Apoptosis in Drosophila EmbryosSemantic proximity Read ↗

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