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Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

18 Jan 2013

Abstract excerpt

Aberrant transcriptional programs in combination with abnormal proliferative signaling drive leukemic transformation. These programs operate in normal hematopoiesis where they are involved in hematopoietic stem cell (HSC) proliferation and maintenance. Ets Related Gene (ERG) is a component of normal and leukemic stem cell signatures and high ERG expression is a risk factor for poor prognosis in acute myeloid...

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PMID: 23327922
DOI: 10.1182/blood-2012-07-446120

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