Role of the extended MAPT haplotype in the worsening of psychotic symptoms and treatment response in Alzheimer disease.

Abstract excerpt

INTRODUCTION: There is evidence that neurofibrillary tangle (NFT) burden is associated with psychotic symptoms in Alzheimer disease (AD). However, it is not clear whether this association is direct or mediated through the increased cognitive impairment associated with NFTs. METHODS: We sought to determine whether the extended MAPT haplotype was associated with the worsening of delusions and hallucinations in a...

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