Article
Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study.
Journal of Alzheimer's disease : JAD - 1 Jan 2009
Angelucci Francesco, Bernardini Sergio, Gravina Paolo, Bellincampi Lorenza, Trequattrini Alberto, Di Iulio Fulvia, Vanni Diego, Federici Giorgio, Caltagirone Carlo, Bossù Paola, Spalletta Gianfranco
Abstract excerpt
Although the etiology of psychotic symptoms (hallucinations and delusions) in Alzheimer's disease is still not known, alterations in serotonergic neurotransmission have been proposed. In a 3-year follow-up study, we evaluated the association of serotonin (5-HT) receptor 5-HT2a 102T/C polymorphism (allelic variants CC, CT and TT) with psychotic symptom severity and response to treatment with atypical...
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