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Article

The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex.

eLife - 10 Oct 2014

Hollopeter Gunther, Lange Jeffrey J, Zhang Ying, Vu Thien N, Gu Mingyu, Ailion Michael, Lambie Eric J, Slaughter Brian D, Unruh Jay R, Florens Laurence, Jorgensen Erik M

Abstract excerpt

The AP2 clathrin adaptor complex links protein cargo to the endocytic machinery but it is unclear how AP2 is activated on the plasma membrane. Here we demonstrate that the membrane-associated proteins FCHo and SGIP1 convert AP2 into an open, active conformation. We screened for Caenorhabditis elegans mutants that phenocopy the loss of AP2 subunits and found that AP2 remains inactive in fcho-1 mutants. A...

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Identifiers

PMID: 25303366
DOI: 10.7554/eLife.03648
PMCID: PMC4215536

Genes

SGIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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