Article
AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis.
eLife - 5 Mar 2013
Gu Mingyu, Liu Qiang, Watanabe Shigeki, Sun Lin, Hollopeter Gunther, Grant Barth D, Jorgensen Erik M
Abstract excerpt
The clathrin adaptor complex AP2 is thought to be an obligate heterotetramer. We identify null mutations in the α subunit of AP2 in the nematode Caenorhabditis elegans. α-adaptin mutants are viable and the remaining μ2/β hemicomplex retains some function. Conversely, in μ2 mutants, the alpha/sigma2 hemicomplex is localized and is partially functional. α-μ2 double mutants disrupt both halves of the complex and are...
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