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Article

Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting.

The Journal of cell biology - 4 Sept 2017

Navarro Negredo Paloma, Edgar James R, Wrobel Antoni G, Zaccai Nathan R, Antrobus Robin, Owen David J, Robinson Margaret S

Abstract excerpt

Acidic clusters act as sorting signals for packaging cargo into clathrin-coated vesicles (CCVs), and also facilitate down-regulation of MHC-I by HIV-1 Nef. To find acidic cluster sorting machinery, we performed a gene-trap screen and identified the medium subunit (µ1) of the clathrin adaptor AP-1 as a top hit. In µ1 knockout cells, intracellular CCVs still form, but acidic cluster proteins are depleted, although...

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Identifiers

PMID: 28743825
DOI: 10.1083/jcb.201602058
PMCID: PMC5584140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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