Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study.

doi:10.1194/jlr.P067454

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Article

Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study.

Journal of lipid research - 1 Jan 2017

Krawczyk Marcin, Rau Monika, Schattenberg Jörn M, Bantel Heike, Pathil Anita, Demir Münevver, Kluwe Johannes, Boettler Tobias, Lammert Frank, Geier Andreas

Abstract excerpt

The PNPLA3 p.I148M, TM6SF2 p.E167K, and MBOAT7 rs641738 variants represent genetic risk factors for nonalcoholic fatty liver disease (NAFLD). Here we investigate if these polymorphisms modulate both steatosis and fibrosis in patients with NAFLD. We recruited 515 patients with NAFLD (age 16-88 years, 280 female patients). Liver biopsies were performed in 320 patients. PCR-based assays were used to genotype the...

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Identifiers

PMID: 27836992
DOI: 10.1194/jlr.P067454
PMCID: PMC5234727

Genes

PNPLA3
MBOAT7

Variants

rs641738

Provenance

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