Article
TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease.
Nature communications - 30 Jun 2014
Liu Yang-Lin, Reeves Helen L, Burt Alastair D, Tiniakos Dina, McPherson Stuart, Leathart Julian B S, Allison Michael E D, Alexander Graeme J, Piguet Anne-Christine, Anty Rodolphe, Donaldson Peter, Aithal Guruprasad P, Francque Sven, Van Gaal Luc, Clement Karine, Ratziu Vlad, Dufour Jean-Francois, Day Christopher P, Daly Ann K, Anstee Quentin M
Abstract excerpt
Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition, strongly associated with the metabolic syndrome, that can lead to progressive hepatic fibrosis, cirrhosis and hepatic failure. Subtle inter-patient genetic variation and environmental factors combine to determine variation in disease progression. A common non-synonymous polymorphism in TM6SF2 (rs58542926 c.449 C>T, p.Glu167Lys) was...
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