Article
A genetic marker of uric acid level, carotid atherosclerosis, and arterial stiffness: a family-based study.
American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Feb 2015
Mallamaci Francesca, Testa Alessandra, Leonardis Daniela, Tripepi Rocco, Pisano Anna, Spoto Belinda, Sanguedolce Maria Cristina, Parlongo Rosa Maria, Tripepi Giovanni, Zoccali Carmine
Abstract excerpt
BACKGROUND: Hyperuricemia associates with atherosclerosis complications, but it is uncertain whether this relationship is causal in nature. The urate transporter GLUT9 (encoded by the SLC2A9 gene) is a major genetic determinant of serum uric acid level in humans. Because polymorphisms are distributed randomly at mating (Mendelian randomization), studies based on GLUT9 polymorphisms may provide unconfounded...
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