Article
A polymorphism in the major gene regulating serum uric acid associates with clinic SBP and the white-coat effect in a family-based study.
Journal of hypertension - 1 Aug 2014
Mallamaci Francesca, Testa Alessandra, Leonardis Daniela, Tripepi Rocco, Pisano Anna, Spoto Belinda, Sanguedolce Maria Cristina, Parlongo Rosa Maria, Tripepi Giovanni, Zoccali Carmine
Abstract excerpt
OBJECTIVES: Hyperuricemia associates with hypertension, but it is uncertain whether this relationship is causal in nature. Glucose transporter 9 (GLUT9) gene is a major genetic determinant of plasma uric acid levels in humans. Since polymorphisms are randomly distributed at mating (Mendelian randomization), studies based on GLUT9 polymorphisms may provide unconfounded assessment of the nature of the link between...
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