Article
Weak Association Between Genetic Markers of Hyperuricemia and Cardiorenal Outcomes: Insights From the STANISLAS Study Cohort With a 20-Year Follow-Up.
Journal of the American Heart Association - 3 May 2022
Kanbay Mehmet, Xhaard Constance, Le Floch Edith, Dandine-Roulland Claire, Girerd Nicolas, Ferreira João Pedro, Boivin Jean-Marc, Wagner Sandra, Bacq-Daian Delphine, Deleuze Jean-François, Zannad Faiez, Rossignol Patrick
Abstract excerpt
Background Hyperuricemia is associated with poor cardiovascular outcomes, although it is uncertain whether this relationship is causal in nature. This study aimed to: (1) assess the heritability of serum uric acid (SUA) levels, (2) conduct a genome-wide association study on SUA levels, and (3) investigate the association between certain single-nucleotide polymorphisms and target organ damage. Methods and Results...
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