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Article

Nasal potential difference: Best or average result for CFTR function as diagnostic criteria for cystic fibrosis?

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 May 2015

Keenan Katherine, Avolio Julie, Rueckes-Nilges Claudia, Tullis Elizabeth, Gonska Tanja, Naehrlich Lutz

Abstract excerpt

BACKGROUND: The current practice of averaging the nasal potential difference (NPD) results of right and left nostril measurements reduce inter-individual variability but may underestimate individual CFTR function. METHODS: Best NPD response to Cl(-)-free and isoproterenol perfusion (=largest ΔPD(0Cl/Iso)) from the right and left nostril was compared to the average result in 13 cystic fibrosis (CF), 78 query-CF...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25300456
DOI: 10.1016/j.jcf.2014.09.006

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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