Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

How the sweat gland reveals levels of CFTR activity.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 May 2022

Wine Jeffrey J

Abstract excerpt

CFTR is an anion channel that causes cystic fibrosis (CF) when its activity, equal to channel number x open probability x conductance (n·PO·γ) is absent or nearly so. CFTR modulators increase CFTR activity, but estimates of in vivo efficacy vary. This review shows how values from the simple and widely used sweat chloride test can be calibrated to provide more accurate estimates of CFTR activity as a percent of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenergic beta-Agonists
Share to Chlorides
Share to Cystic Fibrosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Mutation

Source

Identifiers

PMID: 35184981
DOI: 10.1016/j.jcf.2022.02.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

How the sweat gland reveals levels of CFTR activity.PMID 35184981Read ↗

Assessing accuracy of testing and diagnosis in cystic fibrosis.Semantic proximity Read ↗

Advancements in Sweat Testing Techniques for Cystic Fibrosis: From Classical to Novel MethodsSemantic proximity Read ↗

Real-life application of the optical beta-adrenergic sweat test for people with cystic fibrosis.Semantic proximity Read ↗

In vivo readout of CFTR function: ratiometric measurement of CFTR-dependent secretion by individual, identifiable human sweat glands.Semantic proximity Read ↗

ECFS standards of care on CFTR-related disorders: Diagnostic criteria of CFTR dysfunction.Semantic proximity Read ↗

Diagnostic tools and CFTR functional assays in cystic fibrosis: utility and availability in Switzerland.Semantic proximity Read ↗

Calibrating sweat chloride levels to CFTR activity via ETI effects on CF subjects with one or two F508DEL mutations.Semantic proximity Read ↗

Advancing clinical development pathways for new CFTR modulators in cystic fibrosis.Semantic proximity Read ↗

Sweat chloride as a biomarker of CFTR activity: proof of concept and ivacaftor clinical trial data.Semantic proximity Read ↗

Understanding CFTR Functionality: A Comprehensive Review of Tests and Modulator Therapy in Cystic Fibrosis.Semantic proximity Read ↗

Clinical and primary cell evidence reveals complex CFTR function–phenotype relationshipsSemantic proximity Read ↗

The magnitude of ivacaftor effects on fluid secretion via R117H-CFTR channels: Human in vivo measurements.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.